Molecular Makeup Reveals How CBD & THC Levels Impact Side Effects
High levels of cannabidiol (CBD) in cannabis can offset the neuropsychiatric effects of delta-9-tetrahydrocannabinol (THC) by preventing activation of an emotional processing pathway, according to...
Mike Robinson
1 min read
High levels of cannabidiol (CBD) in cannabis can offset the neuropsychiatric effects of delta-9-tetrahydrocannabinol (THC) by preventing activation of an emotional processing pathway, according to research recently published in JNeurosci.
Previous research has shown that strains of cannabis with high levels of THC and low levels of CBD have increased neuropsychiatric effects, but the exact relationship between CBD and THC was not understood. Hudson et al. investigated the role of the protein ERK, which triggers a signaling pathway implicated in the neuropsychiatric effects of THC.
Reference: “Cannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabinol in the Ventral Hippocampus Through Bi-Directional Control of ERK1-2 Phosphorylation” by Roger Hudson, Justine Renard, Christopher Norris, Walter J. Rushlow and Steven R. Laviolette, 30 September 2019, Journal of Neuroscience.
DOI: 10.1523/JNEUROSCI.0708-19.2019
SOCIETY FOR NEUROSCIENCE OCTOBER 5, 2019
Provided for Educational Purposes, Reprinted with Credit to Authors
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