Application of Nanotechnology in Transdermal Drug Delivery
Just last week researchers from India found in study that nanoparticles have intensive value in the delivery of drugs under to and under our skin. To many in the cannabis and hemp industry this may...
Mike Robinson
3 min read
Just last week researchers from India found in study that nanoparticles have intensive value in the delivery of drugs under to and under our skin. To many in the cannabis and hemp industry this may not be a surprise but gaining the science based evidence of it is very necessary. The word nano itself doesn't quite describe how it's always applied to cannabinoid medicine as generally cannabinoids are reduced but not to that smallest possible level. What many do debate is how effective it is to do this and where there is value – is it in the ingestion of these nanoparticles or in other methods?
In extensive R&D at the GCRC we do look into how nanotechnology plays a vital role in allowing consumers and even terminally ill patients to gain relief faster though the very means this scientific study suggests. The cannabinoid is able to pass through the pore and into the tissue, it then finds it's way in a trickle effect into the blood stream. Because it's been turned into a water soluble substance it will now penetrate the blood cell vs. attach to them at a much greater percentage than oils do. One thing we do know is our blood is not oil and, as well, our body and brain consists of quite a bit of water.
It only makes sense that a water soluble cannabinoid may give better benefit in some fashion than oils – but how has always been the question. This research addresses transdermal application of medicine via the use of nanoparticulate and supports the GCRC Theory that cannabinoid medicine can be more effective when delivered in this manner.
Application of Nanotechnology in Transdermal Drug Delivery
Dilesh Jagdish Singhavi Shagufta Kha First published: 17 November 2020 https://doi.org/10.1002/9781119671732.ch6
Summary
The stratum corneum presents a tough barrier for delivery of drugs through the skin. There is interest in the use of nanoparticles as drug delivery carrier systems because these systems are potentially superior to other carrier systems in terms of controlled release, targeting, and stability. In recent years, a great deal of attention has been given to polymeric nanoparticles for delivering drugs to the skin. A detailed explanation of the interaction of the skin and nanoparticles will enhance the reader's understanding of new concepts and the use of drug delivery carriers in transdermal delivery. The mechanism of penetration/permeation of drug from different nanocarriers plays an important role not only in targeting drugs within skin, but also in development strategies of nanocarriers. This chapter provides an overview of the design of nanocarrier‐based drug delivery systems for transdermal drug delivery. The potential of nanotechnology in transdermal drug delivery is highlighted. The influence of the physicochemical properties of nanocarriers on transdermal drug delivery has also been given attention. Finally, the chapter concludes with future perspectives of nanotechnology in transdermal drug delivery.
Full Article was viewed on the Wiley Online Library
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This article is educational commentary from GCRC. It is not a report of study findings and is not medical advice. Speak with a qualified healthcare professional about your own health.
